Experimental setups for active matter systems inherently include hydrodynamic interactions via the surrounding fluid, often overlooked in theoretical models. However, these interactions can give rise to emergent behaviors distinct from those in "dry" active matter. In this study, we use multi-scale MPCD+MD simulations to examine clustering in mixtures of active and passive spherical particles within spherical confinement. We employ a novel method to enforce no-slip boundary conditions on both particle surfaces and the spherical confinement, which also maintains a stable temperature. We analyze how spatial distributions vary with volume fraction, modeling passive particles as Brownian and active ones as active Brownian particles.